Membrane Anchored hRANKL Cell
CBP74160
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| I. Background | |
| The receptor activator of NF-κB ligand (RANKL) and its receptor RANK are critical regulators for immune responses as well as bone remodeling. RANKL is a type II transmembrane protein that has two forms—a membrane-anchored protein and a secreted protein.The membrane form of RANKL was also expressed on the infiltrating T cells in the rheumatoid synovial fluid and in the gingival tissues of patients with periodontitis. | |
| II. Introduction | |
| Expressed gene: | Membrane Anchored hRANKL |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+5ug/ml puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
| III. Representative Data | |
Figure 1. Membrane Anchored hRANKL Cell flow cytometry data.
Figure 2. Dose response of hRANKL Ab in ADCC Bioassay Effector Cell (High Affinity/NFAT-Jurkat cells) With Membrane Anchored hRANKL Cells (Clone 12).
