PTEN p.R130* Reference Standard

CBP10120

询价

索取COA

产品描述

产品数据库

Introduction
Format	Genomic DNA
Description	PTEN R130* results in a premature truncation of the Pten protein at amino acid 130 of 403 within the phosphatase tensin-type domain (UniProt.org). R130* confers a loss of function to the Pten protein as demonstrated by decreased p53 signaling and increased DNA damage in xenografts (PMID: 24721394) and increased transFormation ability in two different cell lines, as compared to wild-type Pten (PMID: 29533785).

Technical Data
DNA Change:	c.388C>T
AA Change	p.R130*
Mutation type	Substitution - Nonsense
Zygosity	Homozygous
Allelic Frequency	100%
Transcript	ENST00000371953
Cosmic ID	COSM5152
Chr position(GRCh37)	chr10:89692904
Buffer:	Tris-EDTA

Product Information
Intended Use	Research Use Only
Unit Size	1ug
Concentration	Download for COA
Purofication	Download for COA
DNA electrophoresis	Download for COA
Sanger sequencing
Storage	2-8℃
Expiry	36 months from the date of manufacture

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