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PIK3CA p.R38C Reference Standard

CBP10111

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索取COA
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产品数据库
Introduction 
Format Genomic DNA
Description PIK3CA R38C lies within the PI3K-ABD domain of the Pik3ca protein (UniProt.org). R38C confers a gain of function to Pik3ca, as indicated by increased phosphorylation of downstream targets Akt, GSK3-beta, FoxO1, FoxO3a, and S6 in cell culture (PMID: 18829572) and demonstrates increased transFormation ability in two different cell lines, as compared to wild-type Pik3ca (PMID: 29533785).
   
Technical Data 
DNA Change: c.112C>T
AA Change p.R38C
Mutation type Substitution - Missense
Zygosity Heterozygous
Allelic Frequency 50.00%
Transcript ENST00000263967
Cosmic ID COSM744
Chr position(GRCh37) chr3:178916725
Buffer: Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8
Expiry 36 months from the date of manufacture

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