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PIK3CA p.C420R Reference Standard

CBP10328

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Introduction 
Format Genomic DNA
Description PIK3CA C420R lies within the C2 PI3K-type domain of the Pik3ca protein (PMID: 17376864). C420R confers a gain of function on Pik3ca, as indicated by constitutive phosphorylation of downstream targets Akt and S6, and is transforming in cell culture (PMID: 17376864, PMID: 29533785).
   
Technical Data 
DNA Change c.1258T>C
AA Change p.C420R
Mutation type Substitution - Missense
Zygosity Heterozygous
Allelic Frequency 75.00%
Transcript NM_006218.1
Cosmic ID COSM757
Chr position(GRCh37) chr3:178927980
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

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