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ERBB2 p.V842I Reference Standard

CBP10271

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索取COA
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产品数据库
Introduction 
Format Genomic DNA
Description ERBB2 (HER2) V842I lies within the protein kinase domain of the Erbb2 (Her2) protein (UniProt.org). V842I results in increased Erbb2 (Her2) activity, downstream Mapk pathway activation, and the ability to transform cells in culture (PMID: 23220880), however in another study, V842I results in similar cell proliferation and viability levels as wild-type Erbb2 (Her2), in two different cell lines (PMID: 29533785).
   
Technical Data 
DNA Change c.2524G>A
AA Change p.V842I
Mutation type Substitution - Missense
Zygosity Heterozygous
Allelic Frequency 50.00%
Transcript ENST00000269571
Cosmic ID COSM14065
Chr position(GRCh37) chr17:37881332
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

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