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AI-Edigene® ERBB2 p.P780_Y781insGSP Reference Standard Plus

CBP10472

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索取COA
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产品数据库
Introduction 
Gene ERBB2
Description ERBB2 (HER2) P780_Y781insGSP (also referred to as G778_P780dup) results in the insertion of three amino acids in the protein kinase domain of the Erbb2 (Her2) protein between amino acids 780 and 781 (UniProt.org). P780_Y781insGSP results in constitutive activation of Erbb2 (Her2), increased downstream signaling, and is transforming in cell culture (PMID: 23220880, PMID: 28363995, PMID: 29967253).
   
Technical Data 
DNA Change c.2330_2331insGGGCTCCCC
AA Change p.P780_Y781insGSP
Mutation type Insertion - In frame
Zygosity Homozygous
Allelic Frequency 100%
Copy Number 2
Ploidy 2.13
Transcript NM_004448.3
Cosmic ID N/A
Chr position(GRCh37) chr17:37881001_37881002
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

 

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