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TP53 p.P278S Reference Standard

CBP10200

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Introduction 
Format Genomic DNA
Description TP53 P278S lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). P278S results in the loss of Tp53 transactivation of p21, while retaining activation of Axl in cell culture, and promotes tumor growth in xenograft models (PMID: 22989750), and in mouse cells harboring the equivalent mouse variant (P275S), results in decreased activation of Tp53 target genes and reduced apoptotic response following DNA damage (PMID: 11867759).
   
Technical Data 
DNA Change c.832C>T
AA Change p.P278S
Mutation type Substitution - Missense
Zygosity Homozygous
Allelic Frequency 100%
Transcript ENST00000269305
Cosmic ID COSM10939
Chr position(GRCh37) chr17:7577106
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing Download for COA
Storage 2-8
Expiry 36 months from the date of manufacture

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