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TP53 p.C176F Reference Standard

CBP10150

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Introduction 
Format Genomic DNA
Description TP53 C176F lies within a zinc binding residue in the DNA-binding region of the Tp53 protein (UniProt.org). C176F is predicted to confer a loss of function to the Tp53 protein, as demonstrated by the inability to induce CDKN1A (p21) transcription in cell culture (PMID: 22090360).
   
Technical Data 
DNA Change: c.527G>T
AA Change p.C176F
Mutation type Substitution - Missense
Zygosity Heterozygous
Allelic Frequency 33.33%
Transcript ENST00000269305
Cosmic ID COSM10645
Chr position(GRCh37) chr17:7578403
Buffer: Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing Download for COA
Storage 2-8℃
Expiry 36 months from the date of manufacture

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