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TP53 p.C242F Reference Standard

CBP10175

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Introduction 
Format Genomic DNA
Description TP53 C242F lies within a zinc-binding residue in the DNA-binding region of the Tp53 protein (UniProt.org). C242F confers of loss of function to Tp53 as demonstrated by Tp53 destabilization and decreased transactivation activity in cell culture (PMID: 25294809, PMID: 22591662), however, has been reported to demonstrate radiosensitivity similar to wild-type Tp53 (PMID: 19035295).
   
Technical Data 
DNA Change c.725G>T
AA Change p.C242F
Mutation type Substitution - Nonsense
Zygosity Homozygous
Allelic Frequency 100%
Transcript ENST00000269305
Cosmic ID COSM10810
Chr position(GRCh37) chr17:7577556
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture
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