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TP53 p.H179R Reference Standard

CBP10146

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索取COA
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Introduction 
Format Genomic DNA
Description TP53 H179R lies within the DNA binding region of the Tp53 protein (UniProt.org). H179R results in a loss of Tp53 protein function as indicated by failure to activate downstream gene transcription and increased survival (PMID: 17361096, PMID: 26585234), and also induces cancer gene signature through activation of Ras signaling (PMID: 22427690).
   
Technical Data 
DNA Change: c.536A>G
AA Change p.H179R
Mutation type Substitution - Missense
Zygosity Homozygous
Allelic Frequency 100%
Transcript ENST00000269305
Cosmic ID COSM10889
Chr position(GRCh37) chr17:7578394
Buffer: Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

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