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TP53 p.G245S Reference Standard

CBP10152

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Introduction 
Format Genomic DNA
Description TP53 G245S is a hotspot mutation that lies within the DNA binding domain of the Tp53 protein (PMID: 22713868). G245S results in a loss of wild-type Tp53 transcriptional activity, and also confers a gain of function to Tp53, resulting in enhanced Akt signaling and transFormation in cell culture (PMID: 20212049, PMID: 23538418, PMID: 17417775).
   
Technical Data 
DNA Change: c.733G>A
AA Change p.G245S
Mutation type Substitution - Missense
Zygosity Homozygous
Allelic Frequency 100%
Transcript ENST00000269305
Cosmic ID COSM6932
Chr position(GRCh37) chr17:7577548
Buffer: Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture
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