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AI-Edigene® EGFR p.L861Q Reference Standard Plus

CBP10401

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索取COA
产品描述
产品数据库
Introduction 
Format Genomic DNA
Description The L861Q mutation results in an amino acid substitution at position 861 in EGFR, from a leucine (L) to a glutamine (Q). This mutation occurs within exon 21, which encodes part of the kinase domain, and occurs with a frequency of approximately 2% in EGFR-mutated lung tumors (Mitsudomi and Yatabe 2010).
This mutation is associated with increased sensitivity to the EGFR TKIs, erlotinib (Tarceva) and gefitinib (Iressa; Lynch et al. 2004).
   
Technical Data 
DNA Change c.2582T>A
AA Change p.L861Q
Mutation type Substitution - Missense
Zygosity Homozygous
Allelic Frequency 100%
Transcript ENST00000275493
Cosmic ID COSM6213
Chr position(GRCh37) chr7:55259524
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

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