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AI-Edigene® EGFR p.E746_A750delELREA Reference Standard Plus

CBP10418

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索取COA
产品描述
产品数据库
Introduction 
Format Genomic DNA
Description EGFR E746_A750del results in the deletion of five amino acids in the kinase domain of the Egfr protein from amino acids 746 to 750 (PMID: 17318210). E746_A750del results in increased Egfr kinase activity, activation of p44/42 MAPK and AKT in cell culture, promotes tumor growth in xenograft models (PMID: 16373402, PMID: 16912195), and is transforming in cell culture (PMID: 29533785).
   
Technical Data 
DNA Change c.2236_2250del15  GAATTAAGAGAAGCA>-
AA Change p.E746_A750delELREA
Mutation type Deletion - In frame
Zygosity Homozygous
Allelic Frequency 100%
Transcript ENST00000275493
Cosmic ID COSM6225
Chr position(GRCh37) chr7:55242466_55242480
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture
药靶模型联系方式: 华东销售经理:18240630236 全国销售经理:18066071954
诊断标准品联系方式: 华东销售经理:15000320447 华北销售经理:18131625521 华南销售经理:13484295986 华中&西南销售经理:13871580511 全国销售经理:13484295986

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