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TP53 p.P72R (rs1042522-G/G) Reference Standard

CBP10628

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Introduction 
Format Genomic DNA
Description TP53 P72R lies within the CCAR2, HRMT1L2, and WWOX-interacting regions of the Tp53 protein (UniProt.org). P72R is a common polymorphism that decreases Pgc-1a binding, increases mitochondrial function, migration, invasion, and tumor cell metastasis induced by mutant Tp53 in cell culture and in mouse models, but transactivates downstream target genes and inhibits cell growth similar to wild-type Tp53 in culture, and therefore, its effect on Tp53 protein function is unknown.
   
Technical Data 
DNA Change: c.215C>G
AA Change p.P72R
Mutation type Substitution - Missense
Zygosity Homozygous
Allelic Frequency 100%
Transcript NM_000546.6
Cosmic ID COSM250061
Chr position(GRCh38) chr17-7676154-G-C
Buffer: Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purity Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8°C
Expiry 36 months from the date of manufacture

 

 

 

 

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