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TP53 p.Y220C Reference Standard

CBP10144

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Introduction 
Format Genomic DNA
Description TP53 Y220C is a hotspot mutation that lies within the DNA-binding domain (PMID: 17401432). Y220C is predicted to confer a loss of function to the Tp53 protein, as demonstrated by decreased Tp53 transcriptional activity in cell culture (PMID: 16861262, PMID: 23630318).
   
Technical Data 
DNA Change: c.659A>G
AA Change p.Y220C
Mutation type Substitution - Missense
Zygosity Homozygous
Allelic Frequency 100%
Transcript ENST00000269305
Cosmic ID COSM10758
Chr position(GRCh37) chr17:7578190
Buffer: Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

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