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TP53 p.R249G Reference Standard

CBP10158

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Introduction 
Format Genomic DNA
Description TP53 R249G is a hotspot mutation that lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). R249G results in decreased activation of Tp53 target genes, as well as increased proliferation and resistance to apoptosis in cell culture (PMID: 23246812).
   
Technical Data 
DNA Change: c.745A>G
AA Change p.R249G
Mutation type Substitution - Missense
Zygosity Heterozygous
Allelic Frequency 50%
Transcript ENST00000269305
Cosmic ID COSM10668
Chr position(GRCh37) chr17:7577536
Buffer: Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing Download for COA
Storage 2-8℃
Expiry 36 months from the date of manufacture

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