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TP53 p.R213Q Reference Standard

CBP10182

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Introduction 
Format Genomic DNA
Description TP53 R213Q lies within the DNA-binding domain of the Tp53 protein (PMID: 15510160). R213Q results in a mild increase in cell proliferation in culture and increased tumor growth in animal models (PMID: 8080050), and therefore is predicted to confer a loss of function to the Tp53 protein.
   
Technical Data 
DNA Change c.638G>A
AA Change p.R213Q
Mutation type Substitution - Nonsense
Zygosity Homozygous
Allelic Frequency 100%
Transcript ENST00000269305
Cosmic ID COSM10735
Chr position(GRCh37) chr17:7578211
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

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