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TP53 p.H214R Reference Standard

CBP10215

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Introduction 
Format Genomic DNA
Description TP53 H214R lies within the DNA-binding domain of the Tp53 protein (PMID: 15510160). H214R results in increased IL-6 expression and colony Formation compared to wild-type Tp53 in cell culture (PMID: 11920959), and is therefore predicted to confer a gain of function to Tp53.
   
Technical Data 
DNA Change c.641A>G
AA Change p.H214R
Mutation type Substitution - Missense
Zygosity Heterozygous
Allelic Frequency 35.47%
Transcript ENST00000269305
Cosmic ID COSM43687
Chr position(GRCh37) chr17:7578208
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8
Expiry 36 months from the date of manufacture

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