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TP53 p.G245C Reference Standard

CBP10154

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Introduction 
Format Genomic DNA
Description TP53 G245C is a hotspot mutation that lies within the DNA binding domain of the Tp53 protein (PMID: 22713868). G245C results in a loss of transactivation of several targets of wild-type Tp53 (PMID: 22170099, PMID: 30126368), and also confers a gain-of-function to Tp53, as demonstrated through inhibition of Ampk activation in cell culture, and leads to increased tumor Formation in mouse models (PMID: 24857548), and increased migration and invasion in culture (PMID: 30126368).
   
Technical Data 
DNA Change: c.733G>T
AA Change p.G245C
Mutation type Substitution - Missense
Zygosity Homozygous
Allelic Frequency 100%
Transcript ENST00000269305
Cosmic ID COSM11081
Chr position(GRCh37) chr17:7577548
Buffer: Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture
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