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NRAS p.Q61L Reference Standard

CBP10311

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Introduction 
Format Genomic DNA
Description NRAS Q61L is a hotsopt mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). Q61L confers a loss of function on Nras protein as indicated by increase Erk and Mek phosphorylation, and activation of Ck2alpha in cell culture (PMID: 27251789).
   
Technical Data 
DNA Change c.182A>T
AA Change p.Q61L
Mutation type Substitution - Missense
Zygosity Homozygous
Allelic Frequency 100%
Transcript ENST00000369535
Cosmic ID COSM583
Chr position(GRCh37) chr1:115256529
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

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