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NRAS p.G12C Reference Standard

CBP10315

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Introduction 
Format Genomic DNA
Description NRAS G12C is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G12C has not been characterized, but can be predicted to confer a loss of function on Nras protein based on the effects of HRAS G12C and KRAS G12C, which result in a loss of response to GTPase-activating proteins, and transFormation of cultured cells (PMID: 26037647, PMID: 6092966).
   
Technical Data 
DNA Change c.34G>T
AA Change p.G12C
Mutation type Substitution - Missense
Zygosity Heterozygous
Allelic Frequency 25.00%
Transcript ENST00000369535
Cosmic ID COSM562
Chr position(GRCh37) chr1:115258748
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

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