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NRAS p.Q61H Reference Standard

CBP10312

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Introduction 
Format Genomic DNA
Description NRAS Q61H is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). Q61H confers a loss of function to Nras protein as indicated by increased GTP-bound Nras, which leads to increased downstream pathway activation and cell proliferation in cell culture (PMID: 23103856).
   
Technical Data 
DNA Change c.183A>T
AA Change p.Q61H
Mutation type Substitution - Missense
Zygosity Heterozygous
Allelic Frequency 66.67%
Transcript ENST00000369535
Cosmic ID COSM585
Chr position(GRCh37) chr1:115256528
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

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