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CTNNB1 p.S37F Reference Standard

CBP10253

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Introduction 
Format Genomic DNA
Description CTNNB1 S37F lies within the ubiquitination recognition motif of the Ctnnb1 protein and occurs at a Gsk3b phosphorylation site on the Ctnnb1 protein (PMID: 10347231). S37F is predicted to confer a gain of function to the Ctnnb1 protein as demonstrated by nuclear accumulation of Ctnnb1 (PMID: 11196159, PMID: 11943721) and increased cell invasion and migration in the context of an EGFR activating mutation (PMID: 29106415).
   
Technical Data 
DNA Change c.110C>T
AA Change p.S37F
Mutation type Substitution - Missense
Zygosity Heterozygous
Allelic Frequency 50.00%
Transcript ENST00000349496
Cosmic ID COSM5662
Chr position(GRCh37) chr3:41266113
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8
Expiry 36 months from the date of manufacture

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