DMS114（人小细胞肺癌细胞）
CBP60171
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| I. General information | |
| Synonyms: | DMS114 |
| Background: | The line was established from cells from a mediastinal biopsy of a patient with small cell carcinoma of the lung. The patient had not received prior therapy. |
| Species: | Homo sapiens, human |
| Tissue: | lung |
| Disease: | carcinoma; small cell lung cancer |
| Gender: | male,68 years,Caucasian |
| Growth Mode: | adherent |
| DNA Profile: | Amelogenin: X CSF1PO: 10,11 D13S317: 13 D16S539: 12 D5S818: 12 D7S820: 10,11 THO1: 8,9.3 TPOX: 8,11 vWA: 16,17 Cobioer’s Cell Line Authentication Service |
| Culture Medium: |
RPMI-1640+10%FBS DMS114完全培养基，# CBP60171M |
| Cryopreservation medium: | 90%FBS+10%DMSO |
| Antigen Expression: | Leu 7 +; My23 +; CD11b + |
| Receptor Expression: | epidermal growth factor (EGF); complement (CR3) |
| Genes Expressed: | adrenocorticotropin (adrenocorticotropic hormone, ACTH); bombesin; glucagon; 17 beta estradiol; oxytocin - neurophysin (OT-NP) |
| Cellular Products: | adrenocorticotropin (adrenocorticotropic hormone, ACTH); bombesin; glucagon; 17 beta estradiol; oxytocin - neurophysin (OT-NP) |
| Tumor Formation: | Yes, Tumors developed within 21 days at 100% frequency (5/5) in nude mice inoculated subcutaneously with 10(7) cells. |
| Comments: | The patient had not received prior therapy. The cells express HLA class I and class II antigens. Early passages of the cells were contaminated with a bovine mycoplasma (Acholeplasma laidlawii) which was cured (prior to cryopreservation) with A. laidlawii antiserum and kanamycin. For more information, please contact Cobioer (4008-750-250). |
