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BRAF L597R/BaF3

CBP73387

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I. Introduction
Cell Line Name: BRAF L597R/BaF3
Host Cell: Ba/F3
Stability: 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Application: Anti-proliferation assay and PD assay
Freeze Medium: 90% FBS+10% DMSO
Complete Culture Medium: RPMI-1640+10%FBS+2ug/ml puromycin
Mycoplasma Status: Negative
 
II. Background
BRAF L597R lies within the protein kinase domain of the Braf protein (UniProt.org). L597R results in activation of Braf as indicated by increased phosphorylation of Mek and Erk in cell culture, is associated with Erk activation in a patient tumor sample, and in one of two cell lines, increased cell proliferation and cell viability compared to wild-type Braf.
 
III. Representative Data

1. WB of BRAF L597R/BaF3

2. Sanger of BRAF L597R/BaF3

Figure 2. Sanger of BRAF L597R/BaF3

3. Anti-proliferation assay

Figure 3. CTG Proliferation Assay of BRAF L597R BaF3 Cells (C3).

 

 

 

 

 

 

 

 

 

药靶模型联系方式: 华东销售经理:18240630236 全国销售经理:18066071954
诊断标准品联系方式: 华东销售经理:15000320447 华北销售经理:18131625521 华南销售经理:13484295986 华中&西南销售经理:13871580511 全国销售经理:13484295986

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