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PDGFRA V658A/BaF3

CBP73379

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I. Introduction
Cell Line Name: PDGFRA V658A/BaF3
Host Cell: Ba/F3
Stability: 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium: 90% FBS+10% DMSO
Complete Culture Medium: RPMI-1640+10%FBS+200ng/ml PDGF-BB
Mycoplasma Status: Negative
 
II. Background

PDGFRA, platelet-derived growth factor receptor alpha, is a receptor tyrosine kinase that activates PI3K/Akt, RAS/MAPK, and JAK/STAT pathways to promote cell proliferation and survival (PMID: 21605429). PDGFRA mutations have been detected in melanoma, AML, peripheral nerve sheath tumors, sarcoma, and neuroendocrine carcinomas (PMID: 23752188, PMID: 20685895), several fusions have also been reported (PMID: 22432087, PMID: 26276769), and amplification has been observed in glioblastoma (PMID: 23438035).

 
III. Representative Data

1.Sanger of PDGFRA V658A/BaF3

Figure 1. PDGFRA V658A/BaF3 V658A

 

 

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