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PDGFRA D842V-G680R/BaF3

CBP73334

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I. Introduction

Cell Line Name:

PDGFRA D842V-G680R/BaF3

Host Cell:

Ba/F3

Stability: 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium: 90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS

Mycoplasma Status:

Negative

 
II. Background

PDGFRA D842V lies within the protein kinase domain of the Pdgfra protein (UniProt.org). D842V results in ligand-independent phosphorylation of Pdgfra, activation of downstream signaling, and is transforming in culture (PMID: 22745105, PMID: 23752188, PMID: 29533785, PMID: 30253204) and confers resistance to PDGFRA inhibitors (PMID: 30389923, PMID: 18955458). 

 
III. Representative Data

1.Sanger of PDPDGFRA D842V-G680R/BaF3

 

Figure 1. PDGFRA D842V-G680R/BaF3  G680R

Figure 2. PDGFRA D842V-G680R/BaF3 D842V

2. Anti-proliferation assay

 

Figure 3. CTG Proliferation Assay of BaF3 PDGFRA D842V/G680R Cells (C1).

 

 

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