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CCDC6-RET [V804M]/BaF3

CBP73216

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I. Introduction
Cell Line Name: CCDC6-RET [V804M]/BaF3
Host Cell: BA/F3
Stability: 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Application: Anti-proliferation assay and PD assay
Freeze Medium: 90% FBS+10% DMSO
Complete Culture Medium: RPMI-1640+10%FBS+2ug/ml puromycin
Mycoplasma Status: Negative
 
II. Background

CCDC6, coiled-coil domain containing 6, has been shown to play a role in the DNA damaging signaling pathway acting as a substrate of ATM (PMID: 17420723). CCDC6 fusions with RET (PMID: 23154560, PMID: 26078337) and BRAF (PMID: 26314551) have been observed in multiple cancer types. 

 
III. Representative Data

1. CCDC6-RET V804M/BaF3

2. Sanger of CCDC6-RET [V804M]/BaF3

Figure 2. Breakpoint of CCDC6-RET V804M/BaF3

Figure 3. Point mutation of CCDC6-RET V804M/BaF3

3.Anti-proliferation assay

Figure 4. CTG Assay for CCDC6-Ret V804M BaF3 Proliferation.


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