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cGAS-KO/NFκB-SEAP/THP-1

CBP74214

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I. Background
Cyclic guanosine monophosphate-adenosine monophosphate adenosine synthetase (cGAS) is a DNA sensor that detects and binds to cytosolic DNA to generate cyclic GMP-AMP (cGAMP). As a second messenger, cGAMP mainly activates the adapter protein STING, which induces the production of type I interferons (IFNs) and inflammatory cytokines.cGAS is extensively involved in the innate immune response, senescence, and tumor immunity, thereby exhibiting a tumor-suppressive function, most of which is mediated by the STING pathway.
 
II. Introduction
Host Cell: THP-1
Expressed gene: cGAS-KO
Stability: 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: RPMI-1640+ 2 mM L-glutamine+ 25 mM HEPES+ 10%FBS+ 100 µg/ml Normocin+ Pen-Strep (100 U/ml-100 µg/ml)
Storage: Liquid nitrogen
 
III. Description of Host Cell Line
Organism: Homo sapiens, human
Tissue: peripheral blood
Disease: acute monocytic leukemia
Morphology: monocyte
Growth Properties: suspension
 
IV. Representative Data
 

 

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