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hIL20/IL22/IL24 Triple Effector Reporter Cell

CBP74228

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I. Background
IL-20, IL-22, and IL-24 are closely related cytokines that belong to the IL-20 subfamily and play an important role in the protection of barrier tissues. They share the heterodimeric IL-20 type I and type II receptors composed of the IL-20Rα and IL-20Rβ chains, and IL-22Rα1 and IL-20Rβ chains, respectively.
 
II. Introduction
Expressed gene: IL20R、IL22R、IL24R
Stability: 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: DMEM+10%FBS+2ug/ml puromycin+200ug/ml hygromycin+5ug/ml blasticidin
Mycoplasma Testing: Negative
Storage: Liquid nitrogen
Application(s): Functional(Report Gene) Assay
 
III. Representative Data

Figure 1. Recombinant hIL20/IL22/IL24 Triple Effector Reporter Cell stably expressing IL22Rα.

Figure 2. Dose Response of Ligands in hlL20/IL22/lL24 Triple Effector Reporter Cells (C30).

Figure 3. Inhibition of Human lL22-induced Reporter Activity by lL22Ra Blocking Ab or lL22 Neutralization Ab in hIL20/IL22/IL24 Triple Effector Reporter Cells (C30).

Figure 4. Inhibition of Human lL20-induced Reporter Activity by lL20 Neutralization Ab in hlL20/IL22/IL24 Triple Effector Reporter Cells(C30).

 

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