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R232-hSTING-KI/NFκB-SEAP/THP-1

CBP74217

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I. Background
Different innate immune pathways converge to Stimulator of interferon genes (STING) and trigger type I interferon responses after recognition of abnormal nucleic acids in the cells. This non-redundant function renders STING a major player in immunosurveillance, and an emerging target for cancer and infectious diseases therapeutics. Beyond somatic mutations that often occur in cancer, the human gene encoding STING protein, TMEM173 (STING1), holds great genetic heterogeneity; R232, HAQ (R71H-G230A-R293Q) and H232 are the most common alleles.
 
II. Introduction
Host Cell: THP-1
Expressed gene: R232-hSTING-KI
Stability: 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: RPMI-1640+ 2 mM L-glutamine+ 25 mM HEPES+ 10%FBS+ 100 µg/ml Normocin+ Pen-Strep (100 U/ml-100 µg/ml)
Storage: Liquid nitrogen
 
III. Description of Host Cell Line
Organism: Homo sapiens, human
Tissue: peripheral blood
Disease: acute monocytic leukemia
Morphology: monocyte
Growth Properties: suspension
 
IV. Representative Data
 

 

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