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KRAS p.Q61L Reference Standard

CBP10303

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Introduction 
Format Genomic DNA
Description KRAS Q61L is a hotspot mutation that lies within a GTP binding region of the Kras protein (UniProt.org). Q61L results in increased activation of ERK and is transforming in cell culture (PMID: 26854029) and therefore, is predicted to result in decreased Kras protein function.
   
Technical Data 
DNA Change c.182A>T
AA Change p.Q61L
Mutation type Substitution - Missense
Zygosity Heterozygous
Allelic Frequency 66.67%
Transcript ENST00000311936
Cosmic ID COSM553
Chr position(GRCh37) chr12:25380276
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

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