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KRAS p.G13C Reference Standard

CBP10299#

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Introduction 
Format Genomic DNA
Description KRAS G13C is a hotspot mutation that lies within a GTP binding region of the Kras protein (UniProt.org). G13C results in decreased Kras GTPase activity, as indicated by increased Ras-GTP, and leads to activation of downstream signaling in cell culture (PMID: 25705018, PMID: 21079152).
   
Technical Data 
DNA Change c.37G>T
AA Change p.G13C
Mutation type Substitution - Missense
Zygosity Heterozygous
Allelic Frequency 50.00%
Transcript ENST00000311936
Cosmic ID COSM527
Chr position(GRCh37) chr12:25398282
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture
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