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KRAS p.G12S Reference Standard

CBP10297

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索取COA
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Introduction 
Format Genomic DNA
Description KRAS G12S is a hotspot mutation that lies within a GTP binding region of the Kras protein (UniProt.org). G12S results in decreased Kras GTP-GDP exchange rate and leads to increased Ras-GTP and activation of downstream signaling in cell culture (PMID: 23455880, PMID: 28484014, PMID: 26184075).
   
Technical Data 
DNA Change c.34G>A
AA Change p.G12S
Mutation type Substitution - Missense
Zygosity Homozygous
Allelic Frequency 100%
Transcript ENST00000311936
Cosmic ID COSM517
Chr position(GRCh37) chr12:25398285
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

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