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HRAS p.G12D Reference Standard

CBP10288

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Introduction 
Format Genomic DNA
Description HRAS G12D is hotspot mutation that lies within the GTP binding domain of the Hras protein (UniProt.org). G12D results in decreased Hras GTPase activity, loss of sensitivity to GTPase-activating proteins, thus leads to transFormation of cells in culture (PMID: 24224811, PMID: 6092966).
   
Technical Data 
DNA Change c.35G>A
AA Change p.G12D
Mutation type Substitution - Missense
Zygosity Heterozygous
Allelic Frequency 50.00%
Transcript ENST00000397596
Cosmic ID COSM484
Chr position(GRCh37) chr11:534288
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

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