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FGFR3 p.V89fs Reference Standard

CBP10503

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Introduction 
Format Genomic DNA
Description FGFR3, fibroblast growth factor receptor 3, is a receptor tyrosine kinase activated upon binding of the FGF ligand, which activates RAS-MAPK and PI3K-AKT pathways (PMID: 22508544). Altered function of FGFR3 in cancer may lead to increased cell proliferation and decreased apoptosis (PMID: 22508544) and mutations and fusions are commonly observed in bladder cancer (PMID: 30975452, PMID: 23175443).
   
Technical Data 
DNA Change c.267delG
AA Change p.V89fs 
Mutation type Frame_Shift_Del
Zygosity Heterozygous
Allelic Frequency 50%
Transcript ENST00000481110.2
Cosmic ID N/A
Chr position(GRCh37) chr4:1801138
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

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