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FGFR3 p.S249C Reference Standard

CBP10422

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Introduction 
Format Genomic DNA
Description FGFR3, fibroblast growth factor receptor 3, is a receptor tyrosine kinase activated upon binding of the FGF ligand, which activates RAS-MAPK and PI3K-AKT pathways (PMID: 22508544). Altered function of FGFR3 in cancer may lead to increased cell proliferation and decreased apoptosis (PMID: 22508544) and mutations and fusions are commonly observed in bladder cancer (PMID: 30975452, PMID: 23175443).
   
Technical Data 
DNA Change: c.746C>G
AA Change p.S249C
Mutation type Substitution - Missense
Zygosity Heterozygous
Allelic Frequency 85.00%
Transcript NM_000142.5
Cosmic ID COSM715
Chr position(GRCh37) chr4:1803568
Buffer: Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purity Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

 

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