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FBXW7 p.R479Q Reference Standard

CBP10284

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索取COA
产品描述
产品数据库
Introduction 
Format Genomic DNA
Description FBXW7 R479Q lies within the WD 3 repeat region of the Fbxw7 protein (UniProt.org). R479Q confers a loss of FBXW7-substrate interation and impairs substrate degradation by FBXW7, resulting in sustained NICD and MYC expression (PMID: 17646409, PMID: 25450649).
   
Technical Data 
DNA Change c.1436G>A
AA Change p.R479Q
Mutation type Substitution - Missense
Zygosity Heterozygous
Allelic Frequency 66.67%
Transcript ENST00000281708
Cosmic ID COSM22974
Chr position(GRCh37) chr4:153247366
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

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