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BRAF p.G469R Reference Standard

CBP10236

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索取COA
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Introduction 
Format Genomic DNA
Description BRAF G469R is a hotspot mutation within the protein kinase domain of the Braf protein (UniProt.org). G469R demonstrates intermediate BRAF kinase activity (PMID: 28783719) and results in constitutive ERK activation in cell culture (PMID: 24920063), and in one of two cell lines leads to increased cell proliferation and cell viability compared to wild-type Braf (PMID: 29533785), and is therefore predicted to confer a gain of function to the Braf protein.
   
Technical Data 
DNA Change c.1405G>A
AA Change p.G469R
Mutation type Substitution - Missense
Zygosity Heterozygous
Transcript ENST00000288602
Cosmic ID COSM457
Chr position(GRCh37) chr7:140481403
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing Download for COA
Storage 2-8
Expiry 36 months from the date of manufacture

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