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BRAF p.G464V Reference Standard

CBP10695

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索取COA
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Introduction 
Format Genomic DNA
Description BRAF G464V (also reported as G463V) lies within the protein kinase domain of the Braf protein (UniProt.org). G464V results in increased Braf kinase activity and increased downstream Mek and Erk activation, and in one of two cell lines, increased cell proliferation and viability compared to wild-type Braf in culture.
   
Technical Data 
DNA Change c.1391G>T
AA Change p.G464V
Mutation type Substitution - Missense
Zygosity Heterozygous
Allelic Frequency 50%
Transcript NM_004333.6
Cosmic ID COSM450
Chr position(GRCh37) chr7:140481417
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

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