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AI-Edigene® IDH2 p.R172K Reference Standard Plus

CBP10514

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索取COA
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Introduction 
Format Genomic DNA
Description IDH2 R172K lies within the active site of the Idh2 protein (PMID: 19228619). R172K confers a gain of function to Idh2, as indicated by the increased conversion of alpha-ketoglutarate to the onco-metabolite 2HG (R(-)-2-hydroxyglutarate) in cell culture (PMID: 20171147, PMID: 21326614).
   
Technical Data 
DNA Change c.515G>A
AA Change p.R172K
Mutation type Substitution - Missense
Zygosity Homozygous
Allelic Frequency 100%
Transcript NM_002168.4
Cosmic ID COSM33733
Chr position(GRCh37) chr15:90631838
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8°C
Expiry 36 months from the date of manufacture

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