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RKO-AS45-1(人结肠癌细胞)

CBP60686

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I. General information 
Synonyms: RKO-AS45-1
Species: Homo sapiens, human
Disease: Carcinoma
Morphology: epithelial
Growth Mode: adherent
DNA Profile: Cobioer’s Cell Line Authentication Service
Culture Medium:

MEM+10%FBS+1% Non Essential Amino Acids (NEAA) + 1mM Sodium Pyruvate (NaP)

RKO-AS45-1完全培养基,# CBP60686M
We strongly suggest to purchase the complete medium from Cobioer.

Cryopreservation medium: 90%FBS+10%DMSO
Oncogene: p53 + (underexpressed) Ref
Genes Expressed: p53 + (underexpressed)
Comments: The RKO-AS45-1 cell line was generated from the colon carcinoma RKO (ATCC CRL-2577) cell line by transfection with the open reading frame portions of human cDNAs for GADD45 cloned into the expression vector pCMV. The cells contain a stably integrated cytomegalovirus (CMV) promotor driven expression vector. The cells overexpress Gadd45 RNA and protein.
The GADD45 gene is p53-regulated and the Gadd45 protein interacts with proteins involved in both cell-cycle regulation and DNA repair.The RKO-AS45-1 cell line has reduced ability to repair U.V.-induced DNA damage.The RKO-AS45-1 cell line can be used together with its parental cell line, RKO (ATCC CRL-2577) to investigate the effects of Gadd45 on DNA repair, apoptosis and drug sensitivity.
For more information, please contact Cobioer (4008-750-250).
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