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TFG-MET/BAF3

CBP73391

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I. Introduction
Cell Line Name: TFG-MET/BAF3
Host Cell: Ba/F3
Stability: 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Application: Anti-proliferation assay and PD assay
Freeze Medium: 90% FBS+10% DMSO
Complete Culture Medium: RPMI-1640+10%FBS+2ug/ml puromycin
Mycoplasma Status: Negative
 
II. Background

TFG, trafficking from ER to golgi regulator, plays a role in regulation of intracellular trafficking and plays a role in the COPII-coated vesicle transport system. TFG fusions, with multiple gene partners, have been identified in several tumor types, including TFG-MET in thyroid carcinoma, TFG-RET in papillary thyroid cancer, TFG-FGFR1 in AML, and TFG-NR4A3 in extraskeletal myxoid chondrosarcoma.

MET, MET proto-oncogene, receptor tyrosine kinase, is a receptor tyrosine kinase, which activates MAPK, PI3K/AKT, SRC, and STAT pathways to promote cell proliferation, invasion, and angiogenesis. MET mutations, exon 14 skipping mutations, and fusions have been identified in a variety of human cancers, including lung cancer, and MET amplification and/or overexpression has been reported in many solid tumors, including biliary tract cancer, breast cancer, NSCLC, gastric cancer, intrahepatic cholangiocarcinoma, and gallbladder carcinoma.

 
III. Representative Data

1. Anti-proliferation assay


药靶模型联系方式: 华东销售经理:18240630236 全国销售经理:18066071954
诊断标准品联系方式: 华东销售经理:15000320447 华北销售经理:18131625521 华南销售经理:13484295986 华中&西南销售经理:13871580511 全国销售经理:13484295986

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