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DRD2/Gα16/HEK293

CBP71306

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I. Background

This gene encodes the D2 subtype of the dopamine receptor, which is coupled to Gi subtype of G protein-coupled receptor. This G protein-coupled receptor inhibits adenylyl cyclase activity. In mice, regulation of D2R surface expression by the neuronal calcium sensor-1 (NCS-1) in the dentate gyrus is involved in exploration, synaptic plasticity and memory formation.A recent study has shown a potential role for D2R in retrieval of fear memories in the prelimbic cortex.

 
II. Introduction
Host Cell:

HEK293

Stability: 20 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: DMEM+10%FBS+400ug/ml G418
Mycoplasma Status: Negative
Storage: Liquid nitrogen immediately upon delivery
Application(s):

Functional assays for DRD2 receptor

Transducer: Gi
 
Ⅲ. Description of Host Cell Line
Organism: Human
Tissue: kidney
Morphology: Epithelial
Growth Properties: Adherent
 
Ⅳ. Representative Data

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