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CB2/CHO

CBP71366

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I. Background
The Cannabinoid receptor 2 (CNR2) is a Gi/o-coupled GPCR expressed in spleen, tonsils, bone marrow and peripheral blood leukocytes.  There is one report that cannabinoid-induced inhibition of helper T cell activation is lost in macrophages obtained from CNR2 knockout mice.  CNR2 is a potential therapeutic target in the treatment of various disease conditions, such as pain, multiple sclerosis, vascular disease, Parkinson's disease, and other central nerve system disorders.
 
II. Introduction
Host Cell:

CHO

Stability: 20 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: N/A
Mycoplasma Status: Negative
Storage: Liquid nitrogen immediately upon delivery
Application(s):

Functional assay for CB2 receptor

Transducer: Gi
 
Ⅲ. Description of Host Cell Line
Organism: Hamster
Tissue: Ovary
Morphology: Epithelial
Growth Properties: Adherent
 
Ⅳ. Representative Data

Figure 1. CP55940 efffect on CHO-CB2 clone 24.


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