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HLA-E aAPC Cell

CBP74242

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I. Background
     HLA-E (Major Histocompatibility Complex, Class I, E) is a Protein Coding gene. Diseases associated with HLA-E include Choriocarcinoma and Senile Entropion.
 
II. Background
    HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. 


Figure 1.  HLA-E aAPC Cell 细胞模型原理图
 
III. Introduction
Expressed gene: NKG2A
Stability: 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: F12K +10%FBS+ 3 μg/ml puromycin + 600 μg/ml Hygromycin
Mycoplasma Testing: Negative
Storage: Liquid nitrogen
Application(s): Functional(Report Gene) Assay
 
IV. Representative Data

Figure 2. Dose Response of NKG2A Blocking Ab in NKG2A Effector Reporter Cell(C56) With HLA-E aAPC Cell.

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