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ADCP Bioassay Effector Cell FcγRIa-NFAT/Jurkat

CBP74105

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I. Background

Antibody-dependent cell-mediated phagocytosis (ADCP) is one of the important mechanisms of action for antibody drug development.

 
II. Introduction
Host Cell: Jurkat
Expressed gene: FcγRIa_NFAT
Stability: 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: RPMI-1640+10%FBS+1ug/ml puromycin+800ug/ml hygromycin
Storage: Liquid nitrogen
Application(s): Functional(Report Gene) Assay
 
III. Description of Host Cell Line
Organism: Human
Tissue: Peripheral blood
Disease: Childhood T acute lymphoblastic leukemia
Morphology: Lymphoblast
Growth Properties: Suspension
 
IV.Representative Data

Figure 1. Dose response of Rituximab in ADCP Bioassay Effector Cell FcyRⅠa/NFAT Reporter-Jurkat (C11),the EC50 was 1.94ng/ml.Raji cells as target cells.

  

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