4ig-B7H3(CD276)/CHO
CBP74141
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| I. Background | |
| CD276, CD276 molecule, is also known ad B7-H3 and is a member of the B7 family of immune checkpoint regulators (PMID: 30035102) and may be a co-inhibitory protein for T-cell activation by binding to the IL20RA receptor (PMID: 31308249). Overexpression of CD276 (B7-H3) has been observed to correlate with poor prognosis, cell migration, and cell invasion in many solid tumor types including, endometrial, cervical, breast, kidney, colorectal (PMID: 30035102), non-small cell lung cancer (PMID: 31737785), and meningioma (PMID: 31629137). | |
| II. Introduction | |
| Host Cell: | CHO |
| Expressed gene: | 4ig-B7H3(CD276) |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: |
F12K+10%FBS+5ug/ml puromycin |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| III. Description of Host Cell Line | |
| Organism: | Hamster |
| Tissue: | Ovary |
| Disease: | Hamster Chinese ovary |
| Morphology: | Epithelial |
| Growth Properties: | Adherent |
| IV. Representative Data | |
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