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hGDF/GFRAL&RET Effector Reporter Cell

CBP74186

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I. Background
      GFRAL是GDF15的受体,GDF15通过与GFRAL结合发挥作用,GFRAL在结合 GDF15 后与辅助受体RET结合形成GDF15-GFRAL-RET complex复合物,激活下游AKT, ERK and PLC-ϒ信号通路。
 
II. Introduction
Host Cell: N/A
Stability: 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: DMEM+10%FBS+2ug/ml puromycin+200ug/ml hygromycin+10ug/ml blasticidin
Mycoplasma Testing: Negative
Storage: Liquid nitrogen
Application(s): Functional(Report Gene) Assay
 
III. Representative Data

Figure 1. Recombinant hGDF/GFRAL&RET Effector Reporter Cell constitutively expressing GFRAL.

Figure 2. Recombinant hGDF/GFRAL&RET Effector Reporter Cell constitutively expressing RET.

Figure 3.Dose Response of Recombinant Human GDF-15 in hGDF/GFRAL&RET Effector Reporter Cells (C1).

Figure 4.Inhibition of hGDF-15-induced Reporter Activity by hGDF-15 Neutralization Ab in GDF-15/hGFRAL&Ret Effector Reporter Cell (Clone1).

 

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