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PDL1/Raji

CBP74095

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I. Background
The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T-cells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1 ligands are found on most cancers, and PD-1:PD-L1/2 interaction inhibits T cell activity and allows cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes.
 
II. Description
Recombinant Raji cells expressing human PD-L1 (Programmed Cell Death 1 Ligand 1, CD274, B7 homolog 1 (B7- H1), GenBank accession # NM_014143).
 
III. Introduction
Host Cell: Raji
Expressed gene: PDL1
Stability: 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s): Programmed Cell Death 1 Ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, CD274, PDCD1L1
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: RPMI-1640+10%FBS+200ug/ml hygromycin
Mycoplasma Testing: Negative
Storage: Liquid nitrogen
Application(s): Binding Assay,FACS
 
IV. Description of Host Cell Line
Organism: Human
Tissue: lymphoblast
Disease: Burkitt's lymphoma
Morphology: lymphoblast
Growth Properties: suspension
 
Ⅴ. Representative Data

Figure 1.RecombinantRajicells constitutively expressing human PD-L1 (Programmed Cell Death 1 Ligand 1, CD274, B7 homolog 1 (B7- H1), GenBank accession #NM_014143).

 

Figure 2. Blocking of PD-L1 induced PD-1/SHP2 Reporter Cells (C17) Activity by PD-L1 Blocking Ab with PD-L1 Target cells (suspended).

 

Figure 3. Blocking of PD-1 induced PD-1/SHP2 Reporter Cells (C17) Activity by PD-1 Blocking Ab with PD-L1 Target cells (suspended).

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